Figure 8.

CircRNA is a special alternative splicing product. A. A competitive relationship exists between back-splicing and linear splicing. B. Back-splicing is affected by cis-acting elements and trans-acting factor to promote or inhibit the formation of circRNA. C. Selecting different reverse splicing sites and different conventional splicing modes will result in the generation of different circRNAs. D. CircRNA has the potential to affect the splicing pattern of SRSF1 and downstream genes. CIS, cis-acting element; RBP, RNA binding protein; ESRP1, epithelial splicing regulatory protein 1; QKI, KH domain containing RNA binding; DHX9, DExH-box helicase 9; ADAR1, adenosine deaminase 1; VEGFA, vascular endothelial growth factor A; SRSF1, serine and arginine rich splicing factor 1.