Table 2.
Epidemiological and clinical characteristics.
| CIS (n:12) | RRMS (n:71) | SPMS (n:15) | PPMS (n:23) | TOTAL | p | ||
|---|---|---|---|---|---|---|---|
| Age at diagnosis | Mean (SD) | 32 (14.1) | 28 (9.8) | 37 (12.9) | 40 (9.9) | 31.24 (11.19) | 0.0002∗ |
| Gender | Female (70) | 7 (58.33 %) | 38 (53.52 %) | 12 (80.00 %) | 13 (56.52 %) | 70 (57.85 %) | 0.324∗∗ |
| Male (51) | 5 (41.67 %) | 33 (46.48 %) | 3 (20.00 %) | 10 (43.48 %) | 51 (42.15 %) | Reference group | |
| Onset syndrome | Optic neuritis | 6 (50%) | 13 (18.31%) | 3 (20.00%) | --- | 22 (18.18) | 0.005∗∗ |
| Brainstem syndrome | 4 (33.33%) | 18 (25.35%) | 2 (13.33%) | 3 (13.04%) | 27 (22.31) | 0.059∗∗ | |
| Myelitis | --- | 25 (35.21%) | 4 (26.67%) | 8 (34.78%) | 37 (30.58) | 0.130∗∗ | |
| Other syndromes | 2 (16.67%) | 15 (21.13%) | 6 (40.00%) | 12 (52.17%) | 35 (28.93) | Reference group | |
| Relapses at diagnosis | Median (IR) | 1 (1–1) | 2 (1–3) | 2 (2–3) | 0 (0–0) | 2 (1–3) | 0.0001∗ |
| Time to Diagnosis (months) Median (IR) |
Optic neuritis | 2.5 (2–5) | 12 (1–24) | 73 (24–859) | --- | 7 (2–24) | 0.059∗ |
| Brainstem syndrome | 1.5 (1–37.5) | 7 (2–13) | 48 (24–73) | 31 (14–61) | 8 (2–24) | 0.068∗ | |
| Myelitis | --- | 23 (3–49) | 43 (25–85) | 41 (16–55) | 28 (4–49) | 0.297∗ | |
| Other syndromes | 67 (24–110) | 24 (1–52) | 79 (24–122) | 18 (10–40) | 24 (11–61) | 0.128∗ | |
(∗) Kruskal-Wallis test; (∗∗) Chi2 test. p-value represents the comparison between different phenotypes for baseline variables. p values <0.05, statistically significant.