Table 1.

Allele frequencies of ACE2 variants with altered affinity in European (non-Finnish) and East Asian.

Variant	Wild aa	Position	Mutant aa	Effect on affinity	Direct or indirect	European (non-Finnish)	East Asian
rs778030746	I	21	V	↑	Indirect	0.00002446	0.000
rs756231991	E	23	K	↑	Indirect	0.00001222	0.000
rs4646116	K	26	R	↑	Direct	0.005868	0.00006738
rs1348114695	E	35	K	↓	Direct	0.00001221	0.0001444
rs1192192618	Y	50	F	↓	Indirect	0.00001227	0.000
rs1569243690	N	51	S	↓	Indirect	0.00001229	0.000
rs1325542104	M	62	V	↓	Indirect	0.00001266	0.000
rs1199100713	N	64	K	↑	–	0.00001081	0.000
rs1256007252	F	72	V	↓	Indirect	0.000	0.00007243
rs763395248	T	92	I	↑	Direct	0.00002448	0.000
rs1395878099	Q	102	P	↑	–	0.00002168	0.000
rs142443432	D	206	G	↑	–	0.0006314	0.000
rs148771870	G	211	R	↑	–	0.001944	0.000
rs372272603	R	219	C	↑	–	0.0006950	0.000
rs143936283	E	329	G	↑	–	0.00006510	0.000
rs370610075	G	352	V	↓	Direct	0.00001274	0.000
rs961360700	D	355	N	↓	Indirect	0.00002591	0.000
rs142984500	H	378	R	↑	–	0.0001950	0.000
rs762890235	P	389	H	↓	–	0.00002453	0.000
rs776328956	V	447	F	↑	–	0.00007882	0.000
rs191860450	I	468	V	↑	–	0.00002198	0.01140
rs140473595	A	501	T	↑	–	0.00004746	0.000
rs41303171	N	720	D	↑	–	0.02521	0.000