Table 2.

Association between ACE2 polymorphisms and human diseases/ symptoms in different populations.

Disease/Symptom		Subjects’ characteristic	Variant																Reference(s)
			rs2285666	rs4240157	rs2074192	rs4646188	rs879922	rs2048683	rs233575	rs4646156	rs1978124	rs714205	rs2106809	rs6632677	rs4830542	rs2236306	rs4646142	rs4646155
Cardiac event	Higher risk of AF	EH subjects from the south Xinjiang																	Luo et al., 2019
	Higher risk of AF	Uygur T2D patients																	Liu et al., 2021
	Larger size of LAD	Uygur T2D patients																	Liu et al., 2021
	Lower LVEF	Uygur T2D patients																	Liu C et al., 2018
	Higher parameters (LVMI and SWT) of LVH	Uygur T2D patients																	Liu C et al., 2018
	Higher parameters (LVMI and SWT) of LVH	German men from the Augsburg area																	Lieb et al., 2006
	Higher parameters (LVMI and SWT) of LVH	Male HCM patients																	Wang et al., 2008
	DCM	Donors from North Indian ethnicity																	Kumar et al., 2018
Blood pressure disorder	EH	Subjects from the south Xinjiang																	Pan et al., 2018; Luo et al., 2019
	EH	Dongxiang population																	Yi et al., 2006
	Higher levels of SBP	Donors from Mexico City and surrounding states																	Lozano-Gonzalez et al., 2020
	Higher levels of SBP	Uighurs																	Liu C et al., 2018
	Higher levels of DBP	Donors from Mexico City and surrounding states																	Lozano-Gonzalez et al., 2020
	Higher levels of DBP	Uighurs																	Liu et al., 2018
Dyslipidemia	High LDL-C level	Uygur T2D patients																	Liu et al., 2018
	High LDL-C level	Subjects from the south Xinjiang																	Pan et al., 2018
	High CHOL level	Uygur T2D patients																	Liu C et al., 2018
	High CHOL level	Subjects from the south Xinjiang																	Pan et al., 2018
	High TRIG level	Uygur T2D patients																	Liu C et al., 2018
	High TRIG level	Subjects from the south Xinjiang																	Pan et al., 2018
	Low HDL-C level	Uygur T2D patients																	Liu C et al., 2018
	Low HDL-C level	Subjects from the south Xinjiang																	Pan et al., 2018
Ischemic stroke		Subjects from the south Xinjiang																	Pan et al., 2018
Increased serum sodium level		Uygur T2D patients																	Liu et al., 2021
Lower serum potassium concentration		Uygur T2D patients																	Liu et al., 2021
CAS ≥ 50%		Uygur T2D patients																	Liu C et al., 2018
CAS ≥ 50%		EH subjects from the south Xinjiang																	Luo et al., 2019
CAS ≥ 50%		Uighurs																	Liu C et al., 2018
T2D		Uighurs																	Liu C et al., 2018
Increased MAU level		Uygur T2D patients																	Liu C et al., 2018
Higher level of HsCRP		Uygur T2D patients																	Liu et al., 2021
DR and PDR		Chinese female T2D patients																	Meng et al., 2015
SGA		Neonates																	He et al., 2018

13 ACE2 variants are shown in different colors and have been associated with different diseases or symptoms.

AF, atrial fibrillation; LAD, left atrial end−systolic diameter; LVEF, left ventricular ejection fraction; LVMI, left ventricular mass index; SWT, septal wall thickness; LVH, left ventricular hypertrophy; DCM, dilated cardiomyopathies; EH, essential hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; LDL-C, low-density lipoprotein cholesterol; CHOL, cholesterol; TRIG, triglyceride; HDL-C, high-density lipoprotein cholesterol; CAS, carotid arteriosclerosis stenosis; T2D, type 2 diabetes; MAU, microalbuminuria; HsCRP, high-sensitivity C-reactive protein; DR, diabetic retinopathy; PDR, proliferative diabetic retinopathy; SGA, small-for-gestational-age; HCM, hypertrophic cardiomyopathy.