Table 2.
Studies comparing NLR with other biomarkers (studies involving discussed markers other than PLR, LMR, and d-NLR) among different measured variables.
| Study | Measured variable | Summary of findings |
|---|---|---|
| (68) | COVID-19 diagnosis | SII and NLR were higher in patients with SARS-CoV-2 diagnosis in the multivariate analysis (order of higher AUC: SII > NLR). PLR did not correlate. |
| (71) | Disease severity | Higher hsCAR, higher hsCPAR, and lower PNI correlated in the multivariate analysis, but d-NLR and SII only correlated in the univariate analysis. NLR, PLR, LMR, and AFR did not correlate. |
| (79) | Disease severity | Both CAR and NLR predicted disease severity in the multivariate analysis, but CAR had higher OR (OR = 17.65, p = 0.001 vs. OR = 1.51, p = 0.007). |
| (80) | Disease severity | In this meta-analysis, both NLR and LCR predicted disease severity [order of better prediction: NLR (SMD: 2.404) > LCR (SMD: −0.912)] |
| (61) | Mortality | In cancer patients: higher NLR, lower PNI, higher mGPS, and higher PI all predicted an increased mortality (p < 0.0001 for all), PLR did not. |
| (70) | Mortality | NLR, d-NLR, SII, and PNI all predicted mortality. |
| (81) | Mortality | NLR, d-NLR, and SII all predicted mortality in the univariate analysis; however, only SII was significant in the multivariate analysis. |
| (82) | Mortality | PNI independently predicted mortality in the multivariate analysis (AUC: 0.849). NLR and PLR significantly correlated in the univariate analysis. |
| (64) | Mortality, ICU admission, requiring invasive mechanical ventilation, and dialysis | Higher LCR on day 1 predicted an increased need for ICU admission and invasive mechanical ventilation. NLR could not predict any of the variables on day 1. Lower LCR on day 7 predicted increased mortality, while higher NLR correlated with requiring invasive mechanical ventilation and mortality. |
SII, systemic immune-inflammation index; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; AUC, area under the curve; hsCAR, high-sensitivity C-reactive protein to albumin ratio; hsCPAR, high-sensitivity C-reactive protein to prealbumin ratio; PNI, prognostic nutritional index; LMR, lymphocyte to monocyte ratio; d-NLR, derived-NLR; AFR, albumin to fibrinogen ratio; CAR, C-reactive protein to albumin ratio; OR, odds ratio; LCR, lymphocyte to C-reactive protein ratio; SMD, standardized mean difference; mGPS, modified Glasgow prognostic score; PI, prognostic index.