Table 2.
Demographic and clinical characteristics of 898 tuberculosis cases.
| Characteristics | No. (%) of isolates | No. of isolates BDQ MIC≥0.25μg/ml (3.1%, 28/898) | No. of isolates BDQ MIC <0.25μg/ml (96.9%, 870/898) | Univariate analysis | ||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | ||||
| Gender | ||||||
| Male | 654 (72.8) | 18 | 636 | 0.66 | 0.30–1.46 | 0.30 |
| Female | 244 (27.2) | 10 | 234 | Ref. | ||
| Age | ||||||
| ≤25 | 53 (5.9) | 1 | 52 | 0.58 | 0.85–4.37 | 0.72# |
| 26–44 | 164 (18.3) | 5 | 159 | 0.97 | 0.36–2.60 | 1.00 |
| 45–64 | 349 (38.9) | 11 | 338 | 1.02 | 0.47–2.20 | 1.00 |
| ≥65 | 332 (37.0) | 11 | 321 | 1.11 | 0.51–2.39 | 0.79 |
| Case category | ||||||
| New | 733 (81.6) | 23 | 710 | 1.04 | 0.39–2.77 | 0.92 |
| Previously treated | 165 (18.4) | 5 | 160 | Ref. | ||
| AFB smear | ||||||
| Positive | 513 (57.1) | 19 | 494 | 1.61 | 0.72–3.59 | 0.24 |
| Negative | 348 (38.8) | 8 | 340 | 0.62 | 0.27–1.43 | 0.26 |
| Unknown | 37 (4.1) | 1 | 36 | 0.86 | 0.11–6.49 | 1.00# |
| Chest radiography | ||||||
| Normal | 20 (2.2) | 1 | 19 | 1.66 | 0.21–12.85 | 1.00# |
| Abnormal with cavitation | 217 (24.2) | 3 | 214 | 0.37 | 0.11–1.23 | 0.12# |
| Abnormal without cavitation | 643 (71.6) | 24 | 619 | 2.43 | 0.84–7.08 | 0.13# |
| Abnormal but not related to TB | 15 (1.7) | 0 | 15 | NA | NA | 1.00# |
| Unknown | 3 (0.3) | 0 | 3 | NA | NA | 1.00# |
| Site of tuberculosis | ||||||
| Pulmonary | 782 (87.1) | 24 | 758 | 0.89 | 0.30–2.60 | 1.00# |
| Extrapulmonary | 116 (12.9) | 4 | 112 | Ref. | ||
| Pleural effusion | ||||||
| Yes | 63 (7.0) | 2 | 61 | Ref. | ||
| No | 835 (93.0) | 26 | 809 | 0.98 | 0.23–4.23 | 1.00# |
| Genotype | ||||||
| Genotype Beijing family | 486 (54.1) | 15 | 471 | 0.98 | 0.46–2.08 | 1.00 |
| Non-Beijing family | 412 (45.9) | 13 | 399 | Ref. | ||
| Drug resistance pattern | ||||||
| RR | 202 (22.5) | 5 | 197 | 0.74 | 0.28–1.98 | 0.55 |
| MDR | 608 (67.7) | 20 | 588 | 1.20 | 0.52–2.76 | 0.67 |
| Pre-XDR | 74 (8.2) | 3 | 71 | 1.35 | 0.40–4.58 | 0.72# |
| XDR | 14 (1.6) | 0 | 14 | NA | NA | 1.00# |
AFB smear, acid-fast bacilli smear; RR, rifampicin-resistant; MDR, multidrug-resistant; Pre-XDR, Pre-extensively drug-resistant; XDR, extensively drug-resistant; OR, odds ratio; CI, confidence interval; Ref., reference; and NA, not applicable due to a small no. of cases.
#
Fisher’s exact probability test (two tailed).