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Ang-II activates inflammasome in vascular smooth muscle cells via AT1R. Immunoblots of pro-caspase 1 (p40) and active Casp1 (p20) (A) and pro and mature IL-1β (B) and immunoblot representatives (C) in rat aortic vascular smooth muscle cells (RASMC) treated with Ang-II (0,1 μM) for 8 h or 24h with or without losartan (AT1R antagonist, 10μM). N= 4 to 9. Values are reported as mean ± s.e.m. *P<0.05 vs. vehicle; #P<0.05 vs. in presence of losartan.
