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. 2021 Oct 22;11:768222. doi: 10.3389/fonc.2021.768222

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Copyright © 2021 Tan, Yi, Zhang, Tang, Xu and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tumor progression inhibited by the combination of ultrasound-targeted microbubble destruction (UTMD) and PDL-1 blockade therapy. (A) The timeline of treatments and tumor measurements with different group settings. Groups A and B received the UTMD treatment. Groups B and C received PDL-1 blockade therapy. (B) The illustration of tumor volume measurement with two-dimensional ultrasound. (C) The curve line of tumor growth in a different group setting (n = 5). (D) The representative two-dimensional ultrasound images of tumor size in each group by the time of the first (T1), second (T2), and third (T3) treatments. ***P < 0.001.