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A model of transport process-mediated cisplatin resistance in OSCC. ABC transporters act as transmembrane proteins that result in the efflux of cisplatin from OSCC cells and reduce intracellular drug levels. And extracellular vesicles act as natural carriers of biological signals that can deliver substances such as functional RNAs from cisplatin-resistant OSCC cells to parental cells, thus enabling the propagation of cisplatin resistance in OSCC cells.
