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. 2021 Oct 21;23(10):e27714. doi: 10.2196/27714

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©Adam Lavertu, Tymor Hamamsy, Russ B Altman. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 21.10.2021.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

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Severity of adverse drug reactions (ADRs) at different group resolutions. (A) SAEDR score (x-axis) for 11,981 ADRs with System Organ Class (SOC) groups (y-axis). The dashed blue line indicates an overall median SAEDR score of 0.554. The SAEDR score distributions indicate that cancers and cardiac-related side effects are considered the most severe, with product issues being the least severe. (B) Severity distributions of the Medical Dictionary for Regulatory Activities high-level group terms (HLGTs) within the Cardiac Disorders SOC. There are large differences in severity within these term groups. (C) High-level terms within the Heart Failure HLGTs show a tighter distribution of severity, with "Heart Failure Signs and Symptoms" being the least severe within this group. (D) Individual side effects within the signs and symptoms of heart failure suggest cardiac asthma and ascites (accumulation of fluid in the peritoneal cavity) are the most severe symptoms, and peripheral swelling is the least severe symptom NEC: necrotizing enterocolitis; SAEDR: Severity of Adverse Events Derived from Reddit.