Figure 6.

Onset of testis pathology in Tardbp cKO. H&E images of testis cross sections of prepubertal mice showing the onset of phenotypic changes. At PND8, there was no difference in the cellularity of the seminiferous epithelium between the control (A) and cKO mice (B). At PND12, the cKO testis shows the onset of pathology with decreased cellularity (D) compared with the control (C). Note the difference in the appearance of spermatocytes shown by arrows in panels C and D. The scale bar represents 50 microns. cKO, conditional KO; PND8, postnatal day 8; PND12, postnatal day 12.