Table 1. Cohort Demographic and Clinical Characteristics (N = 212).
| Characteristic | No. (%) |
|---|---|
| Age at diagnosis, y | |
| ≤10 | 23 (11) |
| >10 | 189 (89) |
| Sex | |
| Female | 173 (82) |
| Male | 39 (18) |
| Family history of thyroid cancer | 25 (12) |
| Autoimmune thyroiditisa | 67 (32) |
| Prior radiation exposure | 11 (5) |
| Thyroid cancer predisposing syndromeb | 8 (4) |
| PTC Variant | |
| Classic | 147 (69) |
| Follicular | 31 (15) |
| Diffuse sclerosing | 16 (8) |
| Otherc | 18 (8) |
| T staged | |
| T1 | 84 (40) |
| T2 | 43 (20) |
| T3 | 74 (35) |
| T4 | 11 (5) |
| N stage | |
| N0 | 58 (27) |
| N1a | 60 (28) |
| N1b ipsilateral | 36 (17) |
| N1b bilateral | 58 (27) |
| M stage | |
| M0 | 186 (88) |
| M1 | 26 (12) |
| Tumor size, cm | |
| ≤1.0 | 40% (19) |
| 1.1-2.0 | 70 (33) |
| 2.1-4.0 | 67 (32) |
| >4.0 | 35 (17) |
| Any multifocal disease predicted on preoperative imaging | 60 (28) |
| Pathology results positive for multifocal disease | 57 (95) |
| Pathology results negative for multifocal disease | 3 (5) |
| Any multifocal disease | 98 (46) |
| Unilateral multifocal disease | 25 (12) |
| Unilateral multifocal disease predicted on preoperative imaging | 9 (36) |
| Bilateral multifocal disease | 73 (34) |
| Bilateral multifocal disease predicted on preoperative imaging | 48 (66) |
Abbreviation: PTC, papillary thyroid carcinoma.
a
Autoimmune thyroid disease was defined as Hashimoto thyroiditis or Graves disease diagnosed on history or pathology.
b
Thyroid cancer predisposing syndromes include Cowden, DiGeorge, familial adenomatous polyposis, Li-Fraumeni, and multiple endocrine neoplasia type 2A and 2B syndromes.
c
Other PTC variants include cribriform-morular, oncocytic, solid, tall cell, and mixed.
d
Staging according to the American Joint Committee on Cancer, 7th edition.