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. 2021 Nov 4;326(20):1–12. doi: 10.1001/jama.2021.19499

Figure 3. Association Between Progression to Severe Disease and Prior Vaccination Among Adults Hospitalized With COVID-19.

Figure 3.

An adjusted odds ratio (aOR) less than 1.0 indicated that progression to death or invasive mechanical ventilation after hospital admission for COVID-19 was associated with being unvaccinated compared with being vaccinated.

aModels were adjusted for age group (18-49, 50-64, and ≥65 years), sex, self-reported race and ethnicity, and number of chronic medical comorbidities (0, 1, 2, 3, and ≥4). Models stratified by age group were adjusted for continuous age in years.

bImmunocompromising conditions are defined in the Table.

cAnalysis restricted to COVID-19 case patients with hypoxemia within 24 hours of admission, defined as receiving supplemental oxygen or having an oxygen saturation less than 92% as measured by pulse oximetry.