Table 4.
Additive effects of PTSD-PRS in explaining childhood suicidality using specific environmental adversities individually.
| EUR participants (N = 4619) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model 1 (E effect) | Model 2 (E effect + PTSD-PRS (G)) | Model 3 (E + G + G X E) | |||||||
| OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | |
| Negative life events (z) | 1.64 | 1.51–1.79 | <.001 | 1.64 | 1.501–1.78 | <.001 | 1.64 | 1.51–1.79 | <.001 |
| PTSD-PRS | 1.1 | 0.99–1.23 | 0.091 | 1.14 | 0.96–1.35 | 0.139 | |||
| G X E | 0.99 | 0.95–1.03 | 0.609 | ||||||
| Nagelkerke R2 | 0.061 | 0.063 | 0.063 | ||||||
| Family conflict (z) | 1.67 | 1.53–1.82 | <.001 | 1.67 | 1.53–1.82 | <.001 | 1.66 | 1.52–1.82 | <.001 |
| PTSD-PRS | 1.12 | 1–1.25 | 0.055 | 1.07 | 0.9–1.27 | 0.462 | |||
| G X E | 1.02 | 0.97–1.07 | 0.531 | ||||||
| Nagelkerke R2 | 0.059 | 0.061 | 0.061 | ||||||
| LGB discrimination (binary) | 6.97 | 4.71–9.53 | <.001 | 6.66 | 4.68–9.48 | <.001 | 6.74 | 4.74–9.6 | <.001 |
| PTSD-PRS | 1.09 | 0.97–1.22 | 0.156 | 1.11 | 0.98–1.26 | 0.102 | |||
| G X E | 0.85 | 0.59–1.22 | 0.383 | ||||||
| Nagelkerke R2 | 0.048 | 0.049 | 0.049 | ||||||
| AFR participants (N = 1334) | |||||||||
| Model 1 (E effect) | Model 2 (E effect + PTSD-PRS (G)) | Model 3 (E, G + G X E) | |||||||
| OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | |
| Negative life events (z) | 1.67 | 1.42–1.96 | <.001 | 1.67 | 1.42–1.96 | <.001 | 1.66 | 1.42–1.96 | <.001 |
| PTSD-PRS | 1.2 | 0.92–1.57 | 0.178 | 0.87 | 0.54–1.39 | 0.558 | |||
| G X E | 1.08 | 0.99–1.18 | 0.101 | ||||||
| Nagelkerke R2 | 0.065 | 0.068 | 0.072 | ||||||
| Family conflict (z) | 1.45 | 1.23–1.71 | <.001 | 1.45 | 1.23–1.71 | <.001 | 1.45 | 1.22–1.71 | <.001 |
| PTSD-PRS | 1.21 | 0.93–1.67 | 0.158 | 1.19 | 0.77–1.83 | 0.433 | |||
| G X E | 1.01 | 0.89–1.14 | 0.927 | ||||||
| Nagelkerke R2 | 0.036 | 0.039 | 0.039 | ||||||
| LGB discrimination (binary) | 4.84 | 2.8–8.34 | <.001 | 4.87 | 2.82–8.41 | <.001 | 4.83 | 2.79–8.37 | <.001 |
| PTSD-PRS | 1.23 | 0.93–1.64 | 0.145 | 1.2 | 0.89–1.64 | 0.236 | |||
| G X E | 1.18 | 0.53–2.64 | 0.68 | ||||||
| Nagelkerke R2 | 0.054 | 0.058 | 0.058 | ||||||
| Meta-analysis of EUR and AFR (N = 5953) | |||||||||
| Model 1 (E effect) | Model 2 (E effect + PTSD-PRS (G)) | ||||||||
| OR | 95%CI | p | OR | 95%CI | p | ||||
| Negative life events (z) | 1.647 | 1.53–1.78 | <.001 | 1.642 | 1.524–1.769 | <.001 | |||
| PTSD-PRS | 1.115 | 1.006–1.236 | 0.038 | ||||||
| Family conflict (z) | 1.616 | 1.52–1.78 | <.001 | 1.614 | 1.491–1.747 | <.001 | |||
| PTSD-PRS | 1.128 | 1.073–1.186 | 0.021 | ||||||
| LGB discrimination (binary) | 6.084 | 4.53–8.18 | <.001 | 6.073 | 4.516–8.169 | <.001 | |||
| PTSD-PRS | 1.109 | 1.051–1.169 | 0.061 | ||||||
Abbreviations: EUR = European ancestry; AFR = African Ancestry; E = Environment; G = genetic; OR = odds ratio; CI = confidence interval; LGB = Lesbian, gay, bisexual.