Table 5.
Additive effects of PTSD-PRS in explaining childhood suicidality when added to multiple environmental adversities in a single model.
| EUR participants (N = 4619) | ||||||
|---|---|---|---|---|---|---|
| Model 1 (E effect) |
Model 2 (E effect + PTSD-PRS (G)) |
|||||
| OR | 95%CI | p | OR | 95%CI | p | |
| Negative life events (z-score) | 1.46 | 1.33–1.61 | <.001 | 1.46 | 1.33–1.61 | <.001 |
| Family conflict (z-score) | 1.57 | 1.42–1.74 | <.001 | 1.57 | 1.42–1.74 | <.001 |
| LGBT discrimination (past year, binary) | 3.99 | 2.71–5.86 | <.001 | 3.98 | 2.71–5.85 | <.001 |
| PTSD-PRS | 1.07 | 0.95–1.21 | 0.264 | |||
| Nagelkerke R2 | 0.133 | 0.133 | ||||
| AFR participants (N=1334) | ||||||
| Model 1 (E effect) | Model 2 (E effect + PTSD-PRS (G)) | |||||
| OR | 95%CI | p | OR | 95%CI | p | |
| Negative life events (z-score) | 1.6 | 1.34–1.9 | <.001 | 1.6 | 1.34–1.91 | <.001 |
| Family conflict (z-score) | 1.27 | 1.05–1.54 | 0.016 | 1.26 | 1.04–1.53 | 0.017 |
| LGBT discrimination (past year, binary) | 4.05 | 2.3–7.13 | <.001 | 4.08 | 2.32–7.2 | <.001 |
| PTSD-PRS | 1.22 | 0.91–1.63 | 0.178 | |||
| Nagelkerke R2 | 0.116 | 0.119 | ||||
Abbreviations: EUR = European ancestry; AFR = African Ancestry; E = Environment; G = genetic; OR = odds ratio; CI = confidence interval; LGB = Lesbian, gay, bisexual.