FIGURE 5.

MYCN over-expression overcomes BRG1 deficiency and normalizes hepatocyte proliferation. (A–C) Primary hepatocytes were isolated from WT and BRG1 CKO mice and transduced with adenovirus carrying MYCN expression vector followed by treatment with HGF. Gene expression levels were examined by qPCR and Western. Cell proliferation was measured by EdU staining. (D) Human ALF specimens were stained with indicated antibodies. Linear regression was performed with Graphpad Prism. Data are expressed as mean ± standard deviation (SD). *p < 0.05 (one-way ANOVA with post hoc Scheffe test).