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. 2021 Oct 22;12:755624. doi: 10.3389/fimmu.2021.755624

Table 4.

Summarized effect of ERAP, HLA-C, and KIR combined polymorphisms on the susceptibility to infertility and recurrent implantation failure.

ERAP, HLA-C, KIR combination Associated combination Compared groups p pcorr. OR 95% CI Effect Table
KIR/HLA-C TelAA/C2C2 ALL vs. Fertile 0.009 0.026 2.020 1.16–3.61 ↑ Suppl.4
TelAA/C2C2 RIF vs. Fertile 0.004 0.012 2.321 1.26–4.35 ↑ Suppl.4
ERAP1 rs26653 G>C/HLA-C GG/C2C2 ALL vs. Fertile 0.002 0.022 0.343 0.16–0.72 ↓ Suppl.5
GG/C2C2 RIF vs. Fertile 0.001 0.005 0.252 0.10–0.59 ↓ Suppl.5
CG/C2C2 RIF vs. Fertile 0.002 0.016 3.661 1.56–8.89 ↑ Suppl.5
ERAP1 rs26653 G>C/KIR GG/telBB RIF vs. SIVF 0.001 0.006 0.049 0.00–0.38 ↓ Suppl.7
CG/telBB RIF vs. SIVF 0.003 0.023 14.540 2.00–191.36 ↑ Suppl.7
ERAP1 rs26653 G>C/HLA-C/KIR GG/C2C2/AA+ ALL vs. Fertile 0.003 0.025 0.093 0.01–0.54 ↓ Suppl.13
GG/C2C2/AA+ RIF vs. Fertile 0.004 0.036 0.084 0.01–0.55 ↓ Suppl.13
CG/C2C2/AA+ ALL vs. Fertile 0.002 0.020 17.289 2.08–823.60 ↑ Suppl.13
CG/C2C2/AA+ RIF vs. Fertile 0.001 0.008 25.017 2.69–1275.24 ↑ Suppl.13
ERAP1 rs26618 T>C/HLA-C TT/C2+ RIF vs. Fertile 0.005 0.029 1.741 1.16–2.61 ↑ Suppl.5
ERAP1 rs26618 T>C/KIR TT/cenBB RIF vs. Fertile 0.005 0.045 0.239 0.07–0.72 ↓ Suppl.6
ERAP1 rs26618 T>C/HLA-C/KIR CC/C2+/AA+ ALL vs. Fertile 0.005 0.031 0.084 0.00–0.66 ↓ Suppl.13
ERAP1 rs2287987 T>C/KIR CT/telBB ALL vs. Fertile 0.001 0.007 0.111 0.02–0.46 ↓ Suppl.10
CT/telBB RIF vs. Fertile 0.002 0.016 0.055 0.00–0.47 ↓ Suppl.10
ERAP1 rs6861666 A>G/KIR AA/cenBB ALL vs. Fertile 0.001 0.010 7.435 1.87–43.47 ↑ Suppl.11
AA/cenBB RIF vs. Fertile 0.003 0.029 12.373 1.68–553.07 ↑ Suppl.11
AG/cenBB ALL vs. Fertile 0.002 0.020 0.149 0.03–0.60 ↓ Suppl.11
ERAP2 rs2248374 A>G/KIR GG/cenAB/telAB RIF vs. SIVF 0.002 0.051 6.262 1.66–35.58 ↑ Suppl.12

↑, susceptibility; ↓, protection; IVF-ET, in vitro fertilization embryo transfer; RIF, recurrent implantation failure; SIVF, successful pregnancy after IVF-ET; ALL, all IVF patients; p, probability; pcorr., probability after Bonferroni correction; OR, odds ratio; 95% CI, confidence interval from two-sided Fisher’s exact test.