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. 2021 Oct 22;11:756096. doi: 10.3389/fonc.2021.756096

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Copyright © 2021 Wang, Gu, Zhang, Zhou and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The gene signature predicts worse survival of patients in the training set. (A) Distribution of LASSO coefficients of the E2F-related gene signature. (B) Association between gene signature and the E2F transcription factor family. (C) GSEA validated E2F pathway enrichment in the high-ERS group. (D) ERS was significantly increased in patients who died during follow-up. (E) The patients in the high-ERS group had worse survival. (F) Kaplan-Meier analysis showed a worse OS of patients with higher ERS. (G) tROC analysis showed ERS to be an accurate variable for survival prediction.