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. 2021 Oct 22;11:756096. doi: 10.3389/fonc.2021.756096

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Copyright © 2021 Wang, Gu, Zhang, Zhou and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Verification of gene signatures in different sets. (A, B) GSEA validated E2F pathway enrichment in the validation I and II sets. (C, D) The dead patients in the validation I and II sets showed higher ERS. (E, F) The patients of the high-ERS group in the validation I and II sets had worse survival. (G, H) Patients with higher ERS have a poorer prognosis in the validation I and II sets. (I–K) On the basis of the expression patterns of gene signature, the survival rate of clusters derived from consensus clustering differed greatly. (L) Multivariate Cox regression analysis showed ERS as an independent risk factor for OS in the validation I and II sets.