Table 2.
Comparisons of the clinical and laboratory characteristics of the controlled, uncontrolled, and healthy control groups.
| Controlled(n=12) | Uncontrolled(n=22) | Control group (n=31) | p | |
|---|---|---|---|---|
| Age (years) | 9.6 (9.7) | 10.8 (4.7) | 10.5 (6.3) | 0.854a |
| Sex (M/F) | 6/6 | 11 / 11 | 15/16 | 0.992b |
| Puberty (Prepubertal/pubertal) | 7/6 | 9 / 12 | 11/20 | 0.330b |
| Normal/overweight/obese (n) | 7/3/3 | 8/5/8 | 28/1/2 | <0.001b |
| SW/SV | 9/3 | 13 / 9 | - | 0.354b |
| HV SDS | –0.67 (1.58) | –0.35 (4.49 ) | - | 0.461c |
| BA/CA ratio | 1.08 (0.15) | 1.2 (0.30) | - | 0.075c |
| Hydrocortisone dose (mg/m2/day) | 12.5 ± 4.8 | 13.0 ± 3.7 | - | 0.759d |
| Fludrocortisone (mg/m2/day) | 0.10 (0.14) | 0.08 (0.04) | - | 0.186c |
| BMI SDS | 1.04 ± 0.6 | 1.31 ± 0.7 | –0.34 ± 1.3 | <0.001e |
| SBP SDS | 0.36 (1.7) | 0.0 (1.2) | –0.42 (0.9) | 0.329a |
| DBP SDS | 0.55 ± 1.0 | 0.20 ± 0.8 | 0.48 ± 0.6 | 0.533e |
| FBG (mg/dL) | 83.5 (14.7) | 84.5 (13.0) | 84.5 (13.0) | 0.763a |
| HDL (mg/dL) | 56.6 ± 10.8 | 57.6 ± 9.1 | 52.1 ± 9.6 | 0.196e |
| LDL (mg/dL) | 102.4 ± 32.9 | 98.7 ± 29.7 | 95.5 ± 28.8 | 0.576e |
| TC (mg/dL) | 175.2 ± 33.5 | 174.9 ± 33.8 | 161.5 ± 33.1 | 0.140e |
| TG (mg/dL) | 74.5 (34.8) | 75.0 (49.8) | 79.0 (49.2) | 0,810a |
| 17- OH progesterone (ng/mL) | 2.2 (5.8) | 17.0 (24.4) | - | <0.001c |
| Androstenedione ng/mL | 0.3 (1.2) | 1.6 (7.3) | - | 0.012c |
| CIMT (mm) | 0.45 (0.03) | 0.47 (0.04) | 0.47 (0.07) | 0.127a |
aKruskal–Wallis test, bChi-squares test, cMann–Whitney U test, dStudent’s t-test, eOne way ANOVA test. The values are presented as mean ± SD or median (IQR). M: male, F: female, SW: salt wasting, SV: simple virilizing, HV SDS: Height velocity standard deviation score SDS, BA: Bone age, CA: Chronological age, BMI-SDS: Standard deviation score of body mass index, SBP: Systolic blood pressure, DBP: Diastolic blood pressure, FBG: Fasting blood glucose, HDL: High-density lipoprotein, LDL: Low-density lipoprotein, TC: total cholesterol, TG: triglyceride, CIMT: Carotid intima-media thickness.