Table 1.
Demographic characteristics according to PPI therapy.
| Parameters | PPI Therapy | p | |
|---|---|---|---|
| No current PPI use (G1)n=291 | >4 weeks PPI use (G2)n=91 | ||
| Age, yearsMedian (IQR) | 49 (32-66) | 70 (59-77) | <0.001* |
| Sex, n (%)Female | 111 (38.1) | 32 (35.2) | 0.6** |
| Male | 180 (61.9) | 59 (64.8) | |
| Current smoking status, n (%)No | 219 (75.3) | 50 (54.9) | <0.001** |
| Yes | 72 (24.7) | 41 (45.1) | |
| Comorbidities, n (%)No | 160 (55) | 12 (13.2) | <0.001** |
| Yes | 131 (45) | 79 (86.8) | |
| Hypertension, n (%)No | 187 (67.8) | 36 (39.6) | <0.001** |
| Yes | 89 (32.2) | 55 (60.4) | |
| ACE inh or ARB Therapy, n (%)No | 211 (78.7) | 45 (50.6) | <0.001** |
| Yes | 57 (21.3) | 44 (49.4) | |
| Diabetes mellitus, n (%)No | 226 (82.8) | 64 (71.9) | 0.026** |
| Yes | 47 (17.2) | 25 (28.1) | |
| Antidiabetic Therapy, n (%)No | 238 (88.1) | 64 (72.7) | 0.001** |
| Yes | 32 (11.9) | 24 (27.3) | |
| Place of treatment, n (%)Pandemic service | 245 (84.2) | 54 (59.3) | <0.001** |
| Intensive care unit | 46 (15.8) | 37 (40.7) | |
| Intubation, n (%)No (IQR) | 254 (87.3) | 52 (57.1) | <0.001** |
| Yes | 37 (12.7) | 39 (42.9) | |
| Exitus, n (%)No | 254 (87.3) | 57 (62.6) | <0.001** |
| Yes | 37 (12.7) | 34 (37.4) | |
| Duration of stay in hospital, dayMedian (IQR) | 14 (8-14) | 13 (7-18) | 0.298* |
| Duration of stay in ICU, dayMedian (IQR) | 8 (4-13) | 8 (5-20) | 0.259* |
*Mann–Whitney U test; **Chi-Square test; PPI: proton pump inhibitor; ACE inh: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker; ICU: intensive care unit.