TABLE 3.
Blood vessel stiffness before and after DEANO-induced VSMC relaxation at different pulse pressures.
| Mean pressure (mmHg) |
Peterson’s modulus (Ep, mmHg)
|
||||||||||||||
|
20 PP
|
40 PP
|
60 PP
|
80 PP
|
100 PP
|
|||||||||||
| Basal | DEANO | ΔEp | Basal | DEANO | ΔEp | Basal | DEANO | ΔEp | Basal | DEANO | ΔEp | Basal | DEANO | ΔEp | |
| 80 | (280 ± 9) | (265 ± 6) | (−15 ± 4) | (259 ± 8) | (254 ± 7) | (−5 ± 2) | (248 ± 7) | (248 ± 8) | (0 ± 3) | (241 ± 7) | (242 ± 8) | (1 ± 2) | (234 ± 7) | (238 ± 8) | (4 ± 1) |
| 100 | (328 ± 11) | (310 ± 10) | (−18 ± 4) | (298 ± 10) | (297 ± 11) | (−1 ± 3) | (288 ± 12) | (289 ± 13) | (1 ± 3) | (277 ± 11) | (281 ± 12) | (4 ± 3) | (270 ± 10) | (274 ± 11) | (4 ± 2) |
| 120 | (437 ± 23) | (409 ± 23) | (−28 ± 4) | (388 ± 22) | (387 ± 23) | (−1 ± 5) | (371 ± 22) | (372 ± 23) | (1 ± 4) | (353 ± 20) | (357 ± 21) | (4 ± 3) | (338 ± 18) | (343 ± 18) | (5 ± 2) |
| 140 | (625 ± 45) | (579 ± 43)** | (−46 ± 10) | (545 ± 42) | (543 ± 41) | (−2 ± 7) | (516 ± 41) | (518 ± 41) | (2 ± 6) | (484 ± 36) | (488 ± 37) | (4 ± 6) | (454 ± 31) | (461 ± 32) | (6 ± 4) |
| 160 | (894 ± 79) | (844 ± 73)** | (−51 ± 11) | (798 ± 71) | (796 ± 70) | (−2 ± 9) | (748 ± 65) | (752 ± 67) | (3 ± 10) | (695 ± 60) | (700 ± 60) | (5 ± 8) | (645 ± 50) | (653 ± 53) | (8 ± 7) |
| 180 | (1250 ± 112) | (1216 ± 113) | (−35 ± 15) | (1158 ± 111) | (1155 ± 110) | (−3 ± 14) | (1089 ± 105) | (1089 ± 102) | (−1 ± 14) | (958 ± 96) | (976 ± 103) | (18 ± 9) | (890 ± 84) | (904 ± 90) | (14 ± 7) |
| 200 | (1705 ± 158) | (1659 ± 143)** | (−46 ± 32) | (1502 ± 140) | (1602 ± 146)* | (41 ± 26) | (1424 ± 136) | (1459 ± 151)* | (36 ± 21) | (1339 ± 130) | (1289 ± 147) | (18 ± 16) | (1277 ± 142) | (1211 ± 153) | (19 ± 18) |
Comparisons are made between the Ep at “DEANO” and “Basal” (conditions) at the same pulse pressure. Data is expressed as (Mean ± SEM), n = 7, *p < 0.05; **p < 0.01. Repeated measures two-way ANOVA with Sidak post hoc test for multiple comparisons. PP, pulse pressure (mmHg), ΔEp = EpDEANO–Ep Basal.