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The structure of a large central cavity of L-PGDS (A) and docking models of the complexes with all-trans-retinoic acid (B,C) or PGH2 (D,E) determined by NMR (Shimamoto et al., 2007). The molecule of all-trans-retinoic acid are shown in light blue (B,C). The carbon chain of PGH2 is shown in purple and a 9,11-endoperoxide group, in orange (D,E). Amino acid residues important for the ligand binding and the catalytic activity are shown in panels (C,E), respectively.
