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. 2021 Oct 22;12:718002. doi: 10.3389/fphys.2021.718002

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Copyright © 2021 Urade.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory mechanism of human L-Pgds gene expression in brain-derived TE671 cells (Fujimori et al., 2005, 2008; Fujimori and Urade, 2007). L-Pgds gene expression is lowered by the Notch-Hes signal via an N-box, but enhanced by AP-2β through the AP-2 element. TPA activates PKC, followed by phosphorylation of Hes-1 to cancel the binding of Hes-1 to the N-box. Upstream stimulatory factor-1 (USF-1) activates L-Pgds gene expression through the atypical E-box (aE-box) in the intron 4. Serum starvation induces further L-Pgds gene expression.