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. 2021 Oct 22;12:718002. doi: 10.3389/fphys.2021.718002

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Copyright © 2021 Urade.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional regulation of mouse L-Pgds gene in adipocyte 3T3-L1 cells (Fujimori et al., 2007a). L-Pgds gene expression is activated by liver receptor homolog-1 (LRH-1), one of orphan nuclear receptors, through the LRH-responsive element (LRH-RE) in pre-adipocytes. In the differentiated adipocytes, activation of liver X receptor (LXR) elevates the expression of sterol regulatory element-binding protein-1 (SREBP-1c) through the LXR-responsive element (LXRE), and then SREBP-1c strongly enhances the L-Pgds gene expression via two sterol regulatory elements (SREs) in the promoter region of L-Pgds gene.