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. 2021 Oct 22;9:765021. doi: 10.3389/fchem.2021.765021

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Copyright © 2021 Zhou, Luo, Zeng, Yang, Chen, Zhang, He, Yi, Li and Yi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SCHEME 1 — A reduction-sensitive nanodrug delivery system based on dimeric prodrug@polymeric prodrug micelles for drug delivery. (A) The structure of the star-shaped polymeric prodrug (4-arm PEG-SS-PTX, PSSP) and reduction-sensitive dimer-PTX (PTX-SS-PTX, diP) with disulfide linker. (B) diP was encapsulated into the core of PSSP micelles to obtain diP@PSSP micelles by hydrophobic effect. (C) PTX release mechanism of diP@PSSP micelles in tumor cells.