Figure 10.

3D summary plot of Class I triazolopyrimidines showing the experimental MT-stabilizing activity in the QBI293 assay, the MMGBSA score value (ΔG bind), and the QSAR predicted activity. The experimental MT-stabilizing activity of test compounds is plotted both via color coding and as the log of the average of the activity at 1 and 10 μM in the AcTub assay, relative to positive control, $\text{log}\left(\frac{Avg\mathit{\text{AcTu}}{b}_{1\&10\mu M}}{\mathit{\text{AcTu}}{b}_{0.1\mu M}\text{of}5}\right)$, see Experimental for further details.