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. Author manuscript; available in PMC: 2022 Jan 28.
Published in final edited form as: J Med Chem. 2021 Jan 7;64(2):1073–1102. doi: 10.1021/acs.jmedchem.0c01605

Scheme 4. Reagents and Reaction conditions:

Scheme 4.

a) appropriate ester of 4,4,4-trifluoro-3-methylbutanoic acid, HMDS, n-BuLi, THF, −78 °C, 2.5 h, 70% for 110, 25% for 112; b) TFA, CH2Cl2, 20 °C, 16 h, 68%; c) LiCl, DMSO, 130 °C (microwave irradiation), 3 h, 76%.