Figure 1.

Two protocols for study design used to investigate chronic exposures of C57BL/6 mice to ultra-high magnetic fields that include ¹H MRS and a battery of behavioral tests. Protocol I – mice were exposed to 16.4 T for 3 hours per session, two sessions per week, sham exposures were applied for control mice. Protocol II – one group of mice was exposed to 10.5 T, another group of mice were exposed to 16.4 T, each exposure was 3 hours long, and two exposures were applied per week. Control group of mice underwent sham exposures of the same duration. The forth group of mice was exposed to 16.4 T only for a short time (~2 min) that included a vigorous movement of the mouse holder twenty times in and out of the 16.4 T magnet. For a subgroup of mice (16.4T, control, N = 12 each), the MWM test was repeated 6 weeks after the last B₀ exposure.