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. 2021 Nov 5;158:43. doi: 10.1186/s41065-021-00205-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Differences in the structure at the loop level between primary and cell lines. a Relationship between the identical loop percentage and the probability threshold cutoff used to filter the loops, comparing all data to the full dataset of the corresponding THP-1 cells. b Hi-C heat map at Chr1:214.7-215.9 M (10 kb resolution) of the monocytic primary and THP-1 cells. The squared regions are the loops identified by Peakachu. The panel at the bottom shows the gene (CENPF) expression in this region, together with the loop anchor locations (arrowed) (c) Hi-C heat map at Chr2:33.8-36.2 M (10 kb resolution) of the monocytic primary and THP-1 cells. Annotations are the same as in (b)