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. 2021 Nov 4;22:284. doi: 10.1186/s12931-021-01877-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Transcriptomic comparison between alveolar organoids (AOs) and lung bud organoids (LBOs) in HPS1-disease models. A Principal component analysis (PCA) of the transcriptomes of AOs and LBOs in HPS1-disease models. Log₂ (TPM + 0.01) (transcripts per million) were used for PCA. B Hierarchical clustering based on the expression of lung epithelial cell markers. A heatmap indicating Z-score of each gene. Mean values of log₂ (TPM + 0.01) were used to calculate the Z-score. The following data sets were used: CPM^high progenitor cells, GES163575; Lung bud organoids, GSE121999; Adult AT2 cells, GSE131768; Alveolar organoids, GSE179898 and GSE179899. C Overlapped upregulated or downregulated DEGs on each model and their results of gene ontology enrichment analysis of biological process. D TPM of IL11 on each model. The following data sets were used: adult AT2 cells with normal and IPF conditions, GSE94555