Table 4.
Neuropsychological test scores and neuropsychiatric symptom test scores
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Mean (SD) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Visit 1 | Visit 8 | Visit 1 | Visit 8 | Visit 1 | Visit 8 | Visit 1 | Visit 8 | Visit 1 | Visit 8 | Visit 1 | Visit 8 | ||
| Neuropsychological test score | |||||||||||||
| Digit span backward | − 4.14 | − 4.14 | 0.53 | 0.53 | − 0.35 | − 1.23 | − 1.98 | − 0.60 | − 1.00 | − 0.88 | − 1.39 (1.79) | − 1.26 (1.74) | 0.59 |
| K-BNT | − 3.38 | − 3.84 | − 0.81 | − 0.68 | − 2.80 | − 2.59 | − 1.61 | − 0.81 | − 1.32 | − 1.94 | − 1.98 (1.07) | − 1.97 (1.31) | 0.89 |
| RCFT copy | − 7.20 | − 7.48 | − 1.88 | − 2.00 | − 9.14 | − 9.37 | 0.93 | 1.00 | − 1.23 | − 0.94 | − 3.70 (4.26) | − 3.76 (4.44) | 0.69 |
| SVLT delayed recall | − 2.97 | − 2.97 | − 2.30 | − 2.30 | − 3.40 | − 3.40 | − 1.42 | − 1.63 | − 2.74 | − 2.51 | − 2.57 (0.75) | − 2.56 (0.67) | 0.66 |
| RCFT delayed recall | − 2.34 | − 2.34 | − 2.07 | − 2.07 | − 3.08 | − 2.91 | − 1.23 | − 0.96 | − 2.54 | − 2.36 | − 2.25 (0.68) | − 2.13 (0.72) | 0.11 |
| COWAT semantic | − 2.99 | − 3.21 | − 0.17 | − 2.08 | − 2.56 | − 2.32 | − 1.91 | − 1.40 | − 2.08 | − 2.65 | − 1.94 (1.08) | − 2.33 (0.67) | 0.50 |
| COWAT phonemic | − 2.53 | − 2.53 | − 0.09 | − 0.82 | − 1.39 | − 1.06 | − 1.03 | − 0.15 | − 0.69 | − 2.09 | − 1.15 (0.91) | − 1.33 (0.97) | 0.72 |
| Stroop color reading | − 4.89 | − 4.77 | − 0.57 | − 1.58 | − 4.56 | − 4.43 | − 0.54 | − 0.42 | − 2.77 | − 3.75 | − 2.67 (2.09) | − 2.99 (1.90) | 0.68 |
| CDR | 2 | 2 | 1 | 1 | 1 | 1 | 0.5 | 0.5 | 0.5 | 1 | 1.0 (0.6) | 1.1 (0.55) | 0.32 |
| CDR-SOB | 10 | 10 | 5.5 | 5.5 | 9 | 9 | 3.5 | 3.5 | 3.5 | 6 | 6.3 (3.1) | 6.8 (2.7) | 0.32 |
| K-IADL | 1.67 | 1.78 | 1.4 | 1.3 | 1.8 | 1.8 | 0.5 | 0.5 | 0.7 | 1.33 | 1.21 (0.58) | 1.34 (0.53) | 0.29 |
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Mean (SD) | P value* | P value† | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | K-MMSE | CGA-NPI | |
| K-MMSE and CGA-NPI score | ||||||||||||||||
| Visit 1 | 9 | 9 | 22 | 16 | 16 | 11 | 21 | 2 | 19 | 2 | 17.4 (5.2) | 8.0 (6.0) | ||||
| Visit7 (post-FUS) | 8 | 3 | 20 | 1 | 16 | 7 | 23 | 0 | 18 | 0 | 17.0 (5.7) | 2.2 (3.0) | 0 .58 | 0.042 | ||
| Visit8 (3 months post-FUS ) | 10 | 7 | 18 | 0 | 19 | 14 | 23 | 9 | 13 | 5 | 16.6 (5.1) | 5.2 (5.8) | 0.69 | 0.89 | ||
Wilcoxon signed rank tests were used to compare the difference between the neuropsychological test z scores, CDR, CDR-SOB, K-IADL, K-MMSE and CGA-NPI of Visit 1 and Visit 8. Also, we compared the K-MMSE and CGA-NPI scores of Visit 1 and Visit 7 with same test. P < 0.05 was considered significant. Visit 1: baseline. Visit 7: 2 weeks post-FUS. Visit 8: 3 months post-FUS
CDR clinical dementia rating scale, CDR-SOB CDR sum of boxes, CGA-NPI caregiver-administrated neuropsychiatric inventory, COWAT controlled oral word association test, K-BNT Korean version of the Boston naming test, K-IADL Korean instrumental activities of daily living, Rey-Osterrieth complex figure Test, K-MMSE Korean version of mini-mental state examination, SD standard deviation, SVLT Seoul verbal learning test
*P value: Comparison between Visit 1 and Visit 7
†P value: Comparison between Visit 1 and Visit 8