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. 2021 Oct 22;12:745592. doi: 10.3389/fmicb.2021.745592

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Copyright © 2021 Gong and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The most promising LTBI-RD-related antigens for differential diagnosis of latent tuberculosis infection (LTBI) in the future. LTBI-related antigens are divided into six subtypes, including DosR, TAS, RA, NS, Rpf, and Others. RD-related antigens are divided into 16 subtypes, including RD1-RD15 and Others. Each subtype contains several antigens, each antigen is represented by a bubble, and different subtypes are represented by different colors. The size of the bubble represents the number of antigens in the subtype, and the line thickness represent the strength of the connection. The LTBI-RD-related antigens were identified by using a visualization and exploration software Graph (version 0.9.2, https://gephi.org/) and highlighted with dotted box. Each dot presents an antigen, limited to the space, some antigens’ names were not shown in this figure, the detailed information can be found in Supplementary Tables 1, 2.