FIGURE 5.

Effect of high doses of ethanol in male Glra3^–/– mice. (A) The loss of righting reflex (LORR) assay was used as an index of central nervous system depression. Mice received an intraperitoneal injection of 3.5 g/kg of ethanol and the latency to LORR was measured. Glra3^–/– mice did not differ in their reflex ability compared to WT mice. (B) The ability to recover the righting reflex was measured as duration of LORR, where Glra3^–/– mice recovered at similar times compared to WT mice (n = 10 for WT and n = 9 for Glra3^–/–). Unpaired Student’s t-test. Data are mean ± SEM.