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. 2021 Oct 22;8:754936. doi: 10.3389/fmolb.2021.754936

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Copyright © 2021 Yin, Shen, Gu, Zhang, Liu, Huang, Zhu, Zhong, Huang, Wu, Ou, Zhang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DUBR sponged miR-142–3P and negatively modulated miR-142–3P expression. (A) Starbase2.0 and DIANA were used to predict the DUBR candidate sponge miRNA (miR-142-3P, miR-107, and miR-103-3P were involved in them). The OS plot of miR-142-3P. (B), miR-107 (C) and miR-103-3P (D) in AML. (E) Spearman correlation analysis of relative expression between miR-142-3P and DUBR within AML bone marrow, p < 0.05. (F) RNA pull-down assay and qRT-PCR analysis for the detecting of endogenous miR-142-3P related to the DUBR transcript. SCR or miR-142-3P was transfected into Molm-13 (G) and KG-1 (H) cells. Then, cell viability was measured through CCK8 assay.