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Stability of PI-103BE (9) in cell culture medium.
| Compound | Concentration (μM) and fraction of total drug content (%) in cell culture media | ||||
|---|---|---|---|---|---|
| 0.5 h | 1 h | 3 h | 8 h | 24 h | |
| PI-103BE (9) | 0.04 (1.61%) | 0.01 (0.32%) | 0.00 (0%) | 0.00 (0%) | 0.00 (0%) |
| PI-103BA (10) | 2.39 (97.95%) | 3.08 (97.47%) | 3.52 (96.70%) | 3.55 (96.73%) | 3.53 (96.19%) |
| PI-103 (7) | 0.05 (2.02%) | 0.08 (2.52%) | 0.12 (3.30%) | 0.12 (3.27%) | 0.14 (3.81%) |
