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. Author manuscript; available in PMC: 2021 Nov 5.
Published in final edited form as: Bioorg Med Chem Lett. 2020 May 13;30(14):127258. doi: 10.1016/j.bmcl.2020.127258

Table 3.

Pharmacokinetics parameters of PI-103BE (9) and PI-103 (7) in mice after intraperitoneal injection (IP).

Time Point (h) PI-103BE (9) PI-103 (7)
PI-103 (ng/mL) PI-103BA (10) (ng/mL) PI-103 (ng/mL)
0.5 14.9 ± 0.5 30.6 ± 1.4 0.1 ± 0.0
1 5.4 ± 0.1 44.5 ± 0.9 1.4 ± 0.1
3 1.3 ± 0.1 28.0 ± 1.0 1.0 ± 0.1
8 1.0 ± 0.0 17.2 ± 0.3 0.3 ± 0.0
24 0.4 ± 0.0 6.5 ± 0.2 NF
Cmax 14.9 ng/mL 44.5 ng/mL 1.4 ng/mL
T max 0.5 hr 1.0 hr 3.0 hr
t 1/2 12.4 hr 10.2 hr 2.0 hr
AUC 32.3 ng/mL*h 400.9 ng/mL*h 9.7 ng/mL*h