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. Author manuscript; available in PMC: 2021 Nov 5.
Published in final edited form as: Bioorg Med Chem Lett. 2020 May 13;30(14):127258. doi: 10.1016/j.bmcl.2020.127258

Table 4.

Pharmacokinetics parameters of PI-103BE (9) and PI-103 (7) in mice after oral administration.

Time Point
(hrs)		 PI-103BE (9) PI-103 (7)
PI-103 (7) (ng/mL) PI-103BA (10) (ng/mL) PI-103 (7) (ng/mL)
0.5 ND 402.8 ± 22.4 ND
1 8.2 ± 0.7 709.2 ± 11.9 ND
3 6.5 ± 0.4 516.2 ± 13.9 ND
8 4.1 ± 0.3 354. 2 ± 3.2 ND
24 0.7 ± 0.1 106.4 ± 2.2 ND
Cmax 8.2 ng/mL 709.2 ng/mL 0
T max 1 hr 1 hr ND
t 1/2 6.5 hr 9.2 hr ND
AUC0-24h 88.2 ng/mL*h 8879.9 ng/mL*h 0

±: standard error (SEM) of 5 mice; ND: not detected.