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. 2021 Oct 22;9:755437. doi: 10.3389/fped.2021.755437

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Copyright © 2021 Hoffsten, Markasz, Lilja, Olsson and Sindelar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Biomarkers (n = 37) that differed between the three Control groups, 1, 2, and 3 (blue), and their physiological function (brown, yellow, red, black, light blue, green, pink, and gray). (A) Three control subgroups could be identified by clustering of all biomarkers (n = 189). Significantly different biomarkers (n = 37) between the three control groups (1, 2, and 3) are presented. Higher intensity of red color indicates a higher expression of a given biomarker. (B) The comparison in which the biomarker differed in a comparison. Blue color indicates a significant difference of expression between control groups listed at the top of the column. Note that 23 biomarkers differed between Controls 1 and 2; 16 between Controls 1 and 3; and only 14 between Controls 2 and 3. (C) The function/functions of each biomarker as defined by www.humanproteinatlas.org (brown, yellow, red, black, light blue, green, pink, and gray).