FIG 2.
Proposed UQ8 biosynthetic pathway in F. novicida deduced from the one characterized in E. coli. The corresponding protein identifiers in F. novicida are indicated in parentheses. There are no identified counterparts of UbiD and UbiX in the F. novicida proteome. UbiF is identified only in E. coli, and its functional homolog in F. novicida is a Coq7 hydroxylase. Abbreviations: 4HB, 4-hydroxybenzoic acid; OHB, 3-octaprenyl-4-hydroxybenzoic acid; OPP, octaprenylphenol; DMQ8, C6-demethoxy-ubiquinone 8; DDMQ8, C1-demethyl-C6-demethoxy-ubiquinone 8; UQ8, ubiquinone 8.