FIG 10.

Model for RamB-mediated induction of icl1 expression in M. smegmatis during growth on acetate. The simplified TCA cycle and glyoxylate shunt in M. smegmatis grown on glucose (+ Glucose) or acetate (+ Acetate) are depicted. When two or more alternative pathways are possible, the major pathways are indicated by thick arrows. Succinyl-CoA, which was used as a coinducer of RamB, is highlighted by green boxes. Abbreviations: HOA, 2-hydroxy-3-oxoadipate; HOAS, HOA synthase; ICL, isocitrate lyase; KOR, α-ketoglutarate:ferredoxin oxidoreductase; KGD, α-ketoglutarate decarboxylase; SSA DH, succinic semialdehyde dehydrogenase.