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. 2021 Oct 21;12:757464. doi: 10.3389/fphar.2021.757464

TABLE 2.

Main characteristics and NOS scores of the studies included

Author-year Country Ethnicity No. of cases F/M Age (y) HWE Outcome RFC1/SLC19A1 SLCO1B1 ABCB1 FPGS MTHFR MTHFR TYMS/MS ATIC NOS score
80 A>G rs1051266 521 T>C rs4149056 3435 C>T rs1045642 2752 G > A, rs1544105; 1994 A>G, rs10106 677 C>T rs1801133 1298 A>C rs1801131 2R>3R rs34743033 347 C>G rs2372536
Esmaili M A-2020 Iran Caucasian 74 28/46 Median 5, pediatric Yes Tox a , Prog b AG↗ Tox T↘ Prog TT↘ Prog AC↘ Tox 7
Kotur N-2020 Serbia Caucasian 148 54/94 Median 5.5 (0.9–17.6) Yes Tox G↘ Tox NS c NS NS 7
Liu S G-2017 China Asian 322 NR Median 4 (1.0–15.0) Yes Tox, Prog NS CC↘ Prog NS 7
Den Hoed M-2014 Netherlands Caucasian 134 64/70 Median 5.3 (1.4–18.1) Yes Tox NS NS NS NS 8
Suthandiram S-2014 Malaysia Asian 71 35/36 36.6 ± 14.2 Yes Tox G↘ Tox T↗ Tox TT↗ Tox NS 8
Yanagimachi M-2013 Japan Asian 51 25/26 Median 5.9 (1–15) Yes Tox NS NS NS 6
Chiusolo P-2012 Italy Caucasian 54 25/29 Median 52 (15–78) Yes Tox, Prog GG↘ Prog NS C↘ Tox 8
Faganel K B-2011 Slovenia Caucasian 64 38/26 Median 5 (1.6–16.8) Yes Tox NS NS T↗ Tox NS 3R↘ Tox 8
Faganel K B-2010 Slovenia Caucasian 60 37/23 Pediatric Yes Tox, Prog NS 8
Ashton L J-2009 Australia Caucasian 170 NR Pediatric Yes Prog GG↘ Prog NS 8
Imanishi H-2007 Japan Asian 26 10/16 6.7 ± 4.7 Yes Tox NS NS 8
Shimasaki N-2006 Japan Asian 15 9/6 Median 6 (1–14) Yes Tox G↗ Tox NS 8
Kishi S-2003 America Caucasian 53 23/30 Median 6 (0–18) Yes Tox NS NS 7
Laverdiere C-2002 Canada Caucasian 204 92/112 Pediatric Yes Tox, Prog GG↘ Tox, GG↗ Prog 7
Yang L-2017 China Asian 105 33/72 42.5 ± 17.9 Yes Tox C↗ Tox 1994 A>G NS 8
Avivi I-2014 Israel Caucasian 69 20/49 Median 56 (25–83) Yes Tox C↘ Tox NS NS NS 9
Fukushima H-2013 Japan Asian 103 41/62 Median 7.43 (0.2–19.2) Yes Tox, Prog NS T↗ Tox C↗ Prog, C↗ Tox 8
Tsujimoto S-2016 Japan Asian 56 27/29 Median 5 (0–15) Yes Tox NS NS NS 8
Ma C X-2015 China Asian 178 72/106 Median 30 (18–59) Yes Tox, Prog T↗ Tox 8
Chae H-2020 Korea Asian 117 35/82 Median 9 (5–13) Yes Tox TT↗Tox NS 8
Chang X-2021 China Asian 32 11/21 ≥14 Yes Tox TT↗Tox 8
Giletti-2017 Uruguayan Caucasian 41 12/29 36 ± 13.9 Yes Tox NS 7
Yazicioglu B-2017 Turkey Caucasian 106 39/67 Median 5 (1–17) Yes Tox, Prog NS NS NS 7
Choi Y J-2016 Korea Asian 111 53/58 Median 60 (17–86) Yes Tox T↗Tox 8
Erculj N-2014 Slovenia Caucasian 29 4/25 Median 11 (1–8) Yes Tox T↗Tox NS NS 8
Erculj, N-2012 Slovenia Caucasian 167 87/80 Median 4.7 (0.3–18) Yes Tox, Prog NS NS NS 8
Haase R-2012 Germany Caucasian 34 17/17 7.1 ± 4.8 Yes Tox NS NS 7
D'Angelo V-2011 Italy Caucasian 151 48/103 Pediatric Yes Prog TT↘Prog NS 7
Liu S G-2011 China Asian 181 66/115 5.7 ± 3.6 Yes Tox NS C↘Tox 8
Ruiz-Arg elles G J-2007 Mexico Caucasian 28 7/21 Mean 16.5 (0–40) Yes Tox NS 6
Seidemann-2006 Austria, Germany, Switzerland Caucasian 484 144/340 Pediatric Yes Prog NS 7
Huang Z-2016 China Asian 57 26/31 5.9 ± 4.3 Yes Prog 2752 AA↗Prog 9
Oosterom N-2017 Netherlands Caucasian 108 49/59 Median 5.7 (1–18) Yes Tox NS 7
Radkte S-2013 Germany Caucasian 499 204/295 6.4 ± 4.0 Yes Tox, Prog CC↘Prog 3R↘Tox 8

Note:↗: increase; ↘: reduce.

Abbreviation:

a

Tox: toxicity.

b

Prog: prognosis.

c

NS: no significant association between the genetic polymorphisms and the outcomes.