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. Author manuscript; available in PMC: 2022 Jun 7.
Published in final edited form as: Dev Cell. 2021 Apr 30;56(11):1589–1602.e9. doi: 10.1016/j.devcel.2021.04.012

Figure 7. Toll-2 tyrosine phosphorylation is required for cell intercalation and convergent extension.

Figure 7.

(A) Stills from movies of Toll-6,8 mutant embryos that express Toll-2WT, Toll-2C2YF, or no Toll-2 from the endogenous locus and Spider–GFP (0 min, onset of axis elongation). Cell intercalation is reduced in Toll-2C2YF,6,8 and Toll-2null,6,8 embryos. (B) Axis elongation (tissue AP length relative to t=0) is reduced in Toll-2C2YF,6,8 and Toll-2null,6,8 embryos compared with Toll-2WT,6,8 (p<0.03 at t=30 min). (C) Intercalation errors are increased in Toll-2C2YF,6,8 and Toll-2null,6,8 embryos compared with Toll-2WT,6,8. (D) Model of Toll receptor signaling. Mean±SEM, 4–9 living stage 7–8 embryos/genotype, **p≤0.007, Welch’s t-test. Anterior left, ventral down. Bar, 10 μm.