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. 2021 Nov 2;218(12):e20211349. doi: 10.1084/jem.20211349

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© 2021 Chen et al.

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Figure S3. — ISG induction in TLR3- or MDA5-deficient fibroblasts following EV30 or EV71 infection. (A and B) mRNA levels for CXCL10, MX1, OAS1, and ISG15 in SV40-fibroblasts from three healthy controls (Ctrls), P1, P2, a TLR3^−/− patient, and MDA5 KO SV40-fibroblasts, as quantified by RT-qPCR following 24 h of infection with EV30 (A) or EV71 (B) at an MOI of 5. Mean values ± SD were calculated from three independent experiments. P values were obtained by paired samples t test. ns, P > 0.05; *, P < 0.05; **, P < 0.01; ***, P < 0.001.