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. 2021 Nov 2;218(12):e20211349. doi: 10.1084/jem.20211349

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© 2021 Chen et al.

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Figure S4. — Measurement of HSV-1 susceptibility and EV-induced IFN production in human SV40-fibroblasts. (A and B) Levels of HSV-1 replication (A) and cell viability (B) were assessed for SV40-fibroblasts from three healthy controls (Ctrls), P1, P2, a TLR3^−/− patient, MDA5 KO SV40-fibroblasts, and an IFNAR1^−/− patient, at various time points after infection with HSV-1 at an MOI of 0.001. NI, not infected. (C) Levels of IFNB and IFNL1 mRNA, in SV40-fibroblasts from one healthy control, at various time points after infection with EV30 or EV71 at an MOI of 5. NS, not stimulated. Mean values ± SD were calculated from three independent experiments (A–C).