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(A) Prevalence of PC G1896A variant in HBV genotype A. (Bi) HBV pregenome encapsidation sequence. (Bii) Stem-loop configurations of HBV genotype A with and without substitution at nt1986 (PC) and nt1858 positions. The stem-loop energy (kcal/mol) indicates the thermodynamic stability of the HBV pregenome encapsidation sequence. Lower energy numbers indicate stronger bonds between base pairs.
