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. 2021 Oct 22;8:652443. doi: 10.3389/fmolb.2021.652443

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Copyright © 2021 Luo, Yang, Basourakos, Zuo, Wei, Zhao, Li, Li, Feng, Guo and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change profile of downstream functional proteins after the inhibition of STAT1 activity. (A) Western blotting revealed that, after knocking down the expression of JAK2 by siRNA transfection and repressing the activity of JAK2 by FLUD in C4-2B cells, the expression of CXCR7 and P-JAK2 did not display any change, but the expression of C-Myc and Bcl-2 decreased remarkably. In contrast, the expression of DNA damage marker γH2AX increased apparently, the expression of homologous repairing (HR) protein C-PARP-1 increased accordingly, but the expression of non-homologous end-joining (NHEJ) repairing protein DNA-PKCs decreased measurably. (B) All WB band densities were quantitative analyzed.