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. 2021 Oct 22;8:652443. doi: 10.3389/fmolb.2021.652443

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Copyright © 2021 Luo, Yang, Basourakos, Zuo, Wei, Zhao, Li, Li, Feng, Guo and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ENZ + FLUD strategy synergistically inhibited the growth of CRPC xenografts. (A) Drug protocol of each treatment group. (B) Representative C4-2B subcutaneous tumor of each treatment group. (C) Tumor volume measurements using calipers every 3–5 days. (D) Wet tumor weight at the end of 28 days of treatment. (E) Immunohistochemistry of Ki67 in each treatment group. (F) Ratio of Ki67-positive cells in each treatment group.