TABLE 1.

Clinical assessment considerations

HISTORY
	Medical history including allergy history
	Surgical and dental history, including implants
	Medication history
	History of cosmetic injectables including timeline, products used and any history of complications
Current issue including its evolution and associated symptoms
TIMING	Delayed hypersensitivity tends to present after days to weeks
	Granulomas tend to present after many months
	Biofilms can present at any stage, and tend to be single / asymmetric
EXAMINATION	Confirm presence, location and description of lesions including colour
	Palpate to determine heat, fluctuance, induration or cystic nature
	Check for regional lymphadenopathy
FURTHER TESTS TO CONSIDER (SEE DIAGNOSTIC TESTS SECTION)	Blood tests for inflammatory markers
	Biopsy for histopathology
	HFUS—filler identification and initial assessment of nodule54,55

HFUS: High-frequency ultrasound scan