Table 1.
Fraction of Cell Lines Dependent on Glutaminolysis: Data analysis is based on https://depmap.org/portal/.
| Primary Disease | Lineage | Gene Dependency Rate Formula = ((cell line counts that scores of 0 and −1 represent the median effects of nonessential genes and common core essential genes)/total cell line counts) * 100% |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GLS1 | GLS2 | MYC | SLC1A5 | GLUD1 | GLUL | GLS1/GLUL | GLUD1/GLUL | (GLS1+GLUD1)/GLUL | ||
|
| ||||||||||
| Bile | Cholangiocarcinoma (27) | 88.89 | 96.30 | 100.00 | 100.00 | 85.19 | 44.44 | 2.00 | 1.92 | 3.92 |
| Duct (30) | Gallbladder Adenocarcinoma (3) | 100.00 | 100.00 | 100.00 | 66.67 | 66.67 | 66.67 | 1.50 | 1.00 | 2.50 |
| Blood (44) | ALL (12) | 75.00 | 100.00 | 100.00 | 100.00 | 66.67 | 41.67 | 1.80 | 1.60 | 3.40 |
| AML (21) | 95.24 | 95.24 | 100.00 | 100.00 | 85.71 | 38.10 | 2.50 | 2.25 | 4.75 | |
| CLL (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| CML (7) | 100.00 | 85.71 | 100.00 | 100.00 | 85.71 | 57.14 | 1.75 | 1.50 | 3.25 | |
| Unspecified Leukemia (3) | 66.67 | 100.00 | 100.00 | 100.00 | 66.66 | 66.67 | 1.00 | 1.00 | 2.00 | |
| Bone (28) | Chondrosarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A |
| Choroma (3) | 100.00 | 100.00 | 100.00 | 100.00 (4 cell lines) | 100.00 | 50.00 (4 cell lines) | 2.00 | 2.00 | 4.00 | |
| Ewing Sarcoma (16) | 75.00 | 100.00 | 100.00 | 100.00 | 75.00 | 43.75 | 1.71 | 1.71 | 3.43 | |
| Osteosarcoma (8) | 62.50 | 100.00 | 100.00 | 100.00 | 62.50 | 75.00 | 0.83 | 0.83 | 1.67 | |
| Breast (34) | Breast Adenocarcinoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A |
| Breast Carcinoma (18) | 83.33 | 94.44 | 100.00 | 100.00 | 77.78 | 11.11 | 7.50 | 7.00 | 14.50 | |
| Breast Ductal Carcinoma (15) | 100.00 | 93.33 | 100.00 | 100.00 | 86.67 | 46.67 | 2.14 | 1.86 | 4.00 | |
| Central Nervous | Glioma (50) | 90.00 | 94.00 | 100.00 | 100.00 | 94.00 | 56.00 | 1.61 | 1.68 | 3.29 |
| System (61) | Medulloblastoma (9) | 66.67 | 100.00 | 100.00 | 100.00 | 77.78 | 44.44 | 1.50 | 1.75 | 3.25 |
| Meningioma (2) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| Cervix (11) | Cervical Adenocarcinoma (3) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 66.67 | 1.50 | 1.50 | 3.00 |
| Cervical Carcinoma (4) | 75.00 | 100.00 | 100.00 | 100.00 | 75.00 | 100.00 | 0.75 | 0.75 | 1.50 | |
| Cervical Squamous (4) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 50.00 | 2.00 | 2.00 | 4.00 | |
| Colorectal (37) | Colorectal Adenocarcinoma (37) | 75.68 | 81.08 | 100.00 | 100.00 | 91.89 | 67.57 | 1.12 | 1.36 | 2.48 |
| Embryo (1) | Teratoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 |
| Epidermoid Carcinoma (1) | Skin Squamous (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 |
| Esophagus (23) | Esophagus Adenocarcinoma (3) | 100.00 | 100.00 | 100.00 | 100.00 (5 cell lines) | 66.67 | 40.00 (5 cell lines) | 2.50 | 1.67 | 4.17 |
| Esophagus Squamous (20) | 90.00 | 100.00 | 100.00 | 100.00 | 95.00 | 55.00 | 1.64 | 1.73 | 3.36 | |
| Eye (6) | Retinoblastoma (1) | 0.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A |
| Uveal Melanoma (5) | 100.00 | 80.00 | 100.00 | 100.00 | 100.00 | 60.00 | 1.64 | 1.73 | 3.36 | |
| Fibroblast (1) | Fibroblast Soft Tissue (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 |
| Gastric (26) | Gastric Adenocarcinoma (26) | 80.77 | 88.46 | 100.00 | 100.00 | 80.77 | 38.46 | 2.10 | 2.10 | 4.20 |
| Kidney (23) | Malignant Rhabdoid Tumor (7) | 100.00 | 100.00 | 100.00 | 100.00 (8 cell lines) | 100.00 | 87.50 (8 cell lines) | 1.14 | 1.14 | 2.29 |
| Renal Cell Carcinoma (21) | 76.19 | 90.48 | 100.00 | 100.00 | 85.71 | 57.14 | 1.33 | 1.50 | 2.83 | |
| Liver (22) | Hepatoblastoma (1) | 0.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | 1.00 | 1.00 |
| Hepatocellular Carcinoma (20) | 80.00 | 95.00 | 100.00 | 100.00 | 80.00 | 55.00 | 1.45 | 1.45 | 2.91 | |
| Lung (107) | Lung Carcinoid (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 |
| Mesothelioma (10) | 100.00 | 100.00 | 100.00 | 100.00 | 90.00 | 80.00 | 1.25 | 1.13 | 2.38 | |
| NSCLC (78) | 85.90 | 98.72 | 100.00 | 100.00 | 93.59 | 50.00 | 1.72 | 1.87 | 3.59 | |
| SCLC (18) | 77.78 | 100.00 | 94.44 | 100.00 | 83.33 | 55.56 | 1.40 | 1.50 | 2.90 | |
| Lymphocyte (19) | ATL (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 |
| Hodgkin Lymphoma (2) | 100.00 | 50.00 | 100.00 | 100.00 (3 cell lines) | 100.00 | 66.67 (3 cell lines) | 1.50 | 1.50 | 3.00 | |
| Lymphoma Unspecified (3) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 66.67 | 1.50 | 1.50 | 3.00 | |
| Non Hodgkin Lymphoma (13) | 100.00 | 100.00 | 100.00 | 100.00 (14 cell lines) | 69.23 | 28.57 (14 cell lines) | 3.50 | 2.42 | 5.92 | |
| Ovary (43) | Brenner Tumor (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A |
| Mixed Germ Cell (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| Ovary Adenocarcinoma (38) | 92.11 | 100.00 | 100.00 | 100.00 | 89.47 | 36.84 | 2.50 | 2.43 | 4.93 | |
| Ovary Carcinoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| SCCOHT (2) | 100.00 | 100.00 | 100.00 | 100.00 | 50.00 | 50.00 | 2.00 | 1.00 | 3.00 | |
| Pancreas (34) | Exocrine (34) | 88.24 | 100.00 | 100.00 | 100.00 | 88.24 | 52.94 | 1.67 | 1.67 | 3.33 |
| PNS (20) | Neuroblastoma (20) | 85.00 | 90.00 | 100.00 | 100.00 | 95.00 | 60.00 | 1.42 | 1.58 | 3.00 |
| Plasma (21) | Multiple Myeloma (21) | 100.00 | 95.24 | 100.00 | 100.00 | 76.19 | 71.43 | 1.40 | 1.07 | 2.47 |
| Prostate (1) | Prostate Adenocarcinoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A |
| Skin (52) | Melanoma (46) | 87.00 | 93.48 | 100.00 | 100.00 (47 cell lines) | 80.43 | 53.19 (47 cell lines) | 1.63 | 1.51 | 3.15 |
| Merkel Cell Carcinoma (2) | 100.00 | 100.00 | 100.00 | 100.00 (3 cell lines) | 100.00 | 33.33 (3 cell lines) | 3.00 | 3.00 | 6.00 | |
| Skin Squamous (4) | 100.00 | 100.00 | 100.00 | 100.00 | 50.00 | 25.00 | 4.00 | 2.00 | 6.00 | |
| Soft Tissue (39) | ATRT (3) | 66.67 | 100.00 | 100.00 | 100.00 (5 cell lines) | 100.00 | 20.00 (5 cell lines) | 3.33 | 5.00 | 8.33 |
| Epithelioid Sarcoma (2) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 50.00 | 2.00 | 2.00 | 4.00 | |
| Fibrosarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| Leiomyosarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 (2 cell lines) | 100.00 | 50.00 (2 cell lines) | 2.00 | 2.00 | 4.00 | |
| Liposarcoma (8) | 100.00 | 87.50 | 100.00 | 100.00 | 100.00 | 37.50 | 2.67 | 2.67 | 5.33 | |
| Malignant Rhabdoid Tumor (7) | 85.71 | 85.71 | 100.00 | 100.00 (8 cell lines) | 100.00 | 37.50 (8 cell lines) | 2.29 | 2.67 | 4.95 | |
| Pleomorphic Sarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| Rhabdomyosarcoma (11) | 81.82 | 90.91 | 100.00 | 100.00 | 54.55 | 36.36 | 2.25 | 1.50 | 3.75 | |
| Synovial Sarcoma (5) | 80.00 | 100.00 | 100.00 | 100.00 | 80.00 | 60.00 | 1.33 | 1.33 | 2.67 | |
| Thyroid Sarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| Undifferentiated Sarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | 0.00 | N/A | N/A | N/A | |
| Thyroid (6) | Thyroid Carcinoma (5) | 80.00 | 80.00 | 100.00 | 100.00 | 80.00 | 40.00 | 2.00 | 2.00 | 4.00 |
| Thyroid Squamous (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| Upper Aerodigestive (32) | Upper Aerodigestive Squamous (32) | 87.50 | 90.63 | 100.00 | 100.00 (33 cell lines) | 90.63 | 45.45 (33 cell lines) | 1.93 | 1/99 | 3.92 |
| Urinary Tract (29) | Bladder Carcinoma (29) | 75.86 | 93.10 | 96.55 | 100.00 | 96.55 | 55.17 | 1.38 | 1.75 | 3.13 |
| Uterus (26) | Choriocarcinoma (2) | 0.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | 1.00 | 1.00 |
| Clear Cell Carcinoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| Endometrial Adenocarcinoma (15) | 60.00 | 100.00 | 100.00 | 100.00 | 73.33 | 73.33 | 0.82 | 1.00 | 1.82 | |
| Endometrial Adenosquamous (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 1.00 | 1.00 | 2.00 | |
| Endometrial Squamous (3) | 66.67 | 100.00 | 100.00 | 100.00 | 100.00 | 66.67 | 1.00 | 1.50 | 2.50 | |
| Endometrial Stromal Sarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| MMMT (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| Mullerian Carcinoma (1) | 0.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |
| Uterine Carcinosarcoma (1) | 100.00 | 100.00 | 100.00 | 100.00 | 100.00 | 0.00 | N/A | N/A | N/A | |